Severe coronavirus disease 2019 in pediatric solid organ transplant recipients: Big data convergence study in Korea (K-COV-N cohort)open access
- Authors
- Kang, Ji-Man; Kang, Minsun; Kim, Young-Eun; Choi, Yoonkyung; An, Soo Jeong; Seong, Jaehyun; Go, Min Jin; Huh, Kyungmin; Jung, Jaehun
- Issue Date
- Sep-2023
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Solid organ transplant; Children; Severe COVID-19; Relative risk; Korea
- Citation
- INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.134, pp.220 - 227
- Journal Title
- INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Volume
- 134
- Start Page
- 220
- End Page
- 227
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89020
- DOI
- 10.1016/j.ijid.2023.06.016
- ISSN
- 1201-9712
- Abstract
- Objectives: The risk of severe COVID-19 in children with a solid organ transplant (SOT) is not well es-tablished. We compare the relative risk of severe COVID-19 infection between pediatric SOT and non-SOT children.Methods: The newly constructed K-COV-N cohort (Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service) was used. Children with COVID-19 ( < 18 years old) who under-went SOT between January 2008 to January 2022 were included. Non-SOT children with COVID-19 were selected in a ratio of 1:4 using propensity score matching. Three definitions of severe COVID-19 were established based on their requirement for respiratory support: severe I (requiring respiratory support above a high-flow nasal cannula or prolonged hospitalization & GE;6 days), severe II (requiring any oxygen supplement), and severe III (requiring any oxygen supplement or prolonged hospitalization & GE;6 days).Results: Among 2,957,323 children with COVID-19, 206 pediatric SOT recipients (SOTRs) were identified and included in the analysis along with 803 matched non-SOT children. Most infections (96.6%) occurred during the Omicron period; no cases of mortality were reported. Pediatric SOTR had a 3.6-fold (95% con-fidence interval = 1.1-11.7, P = 0.03) higher risk of severe I, and a 4.9-fold (95% confidence interval = 1.6-15.0, P = 0.006) higher risk of severe III than non-SOT children. No cases of severe II occurred in the non-SOT children. Although not statistically significant, no severe COVID-19 cases were reported in the vaccinated SOT group (0.0% vs 5.7%, P = 0.09 in severe III).Conclusion: Pediatric SOTRs have a significantly higher risk of severe COVID-19 than non-SOT children. Our findings support the need for tailored strategies for these high-risk children.& COPY; 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.