청피의 항염증효과Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells
- Other Titles
- Effects of Citri Reticulatae Viride Pericarpium on 4-Hydroxynonenal-Induced Inflammation in PC12 Cells
- Authors
- 예영준; 김연섭; 강미숙
- Issue Date
- 2016
- Publisher
- 한방비만학회
- Keywords
- Citri Reticulatae Viride Pericarpium; 4-HNE; pJNK; pNF-kB
- Citation
- 한방비만학회지, v.16, no.2, pp.79 - 82
- Journal Title
- 한방비만학회지
- Volume
- 16
- Number
- 2
- Start Page
- 79
- End Page
- 82
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8919
- ISSN
- 1976-9334
- Abstract
- Objectives: The purpose of this study was to observe the effects of Citri Reticulatae ViridePericarpium (CP) on 4-Hydroxynonenal (4-HNE)-induced inflammation in PC12 cells.
Methods: 4-HNE was treated in PC12 cell to cause inflammatory response, and then treated withCP water extract at 25, 50, and 100 g/ml. The phosphorylation of Jun N-terminal kinase (JNK)and the expression of NF-B in PC12 cells were determined by Western blot, respectively.
Results: The phosphorylation of JNK was significantly decreased in 4-HNE-stimulated PC12 cellby the treatment of CP extract at 25 g/ml. The 4-HNE-induced expression of nuclear factorkappa-light-chain-enhancer of activated B cells (NF-B) p65 in nuclear of the cells wassignificantly decreased in PC12 cell by treatment with CP extract at 25, 50, and 100 g/ml.
Conclusions: These results suggest that CP water extract has an anti-inflammatory activitythrough suppressing the JNK and NF-B activation.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의학과 > 1. Journal Articles
- 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8919)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.