Hizikia Fusiformis Hexane Extract Decreases Angiogenesis in Vitro and in VivoHizikia fusiformis 추출물의 in vitro 및 in vivo에서 혈관신생 감소 연구
- Other Titles
- Hizikia fusiformis 추출물의 in vitro 및 in vivo에서 혈관신생 감소 연구
- Authors
- 제갈명은; 한유선; 박시영; 이지혁; 이의연; 김영진
- Issue Date
- Sep-2023
- Publisher
- 한국생명과학회
- Keywords
- Anti-angiogenesis; brown algae; Hizikia fusiformis; natural extracts; vascular endothelial growth factor (VEGF)
- Citation
- 생명과학회지, v.33, no.9, pp.703 - 712
- Journal Title
- 생명과학회지
- Volume
- 33
- Number
- 9
- Start Page
- 703
- End Page
- 712
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89229
- DOI
- 10.5352/JLS.2023.33.9.703
- ISSN
- 1225-9918
- Abstract
- Angiogenesis, the formation of blood vessels from pre-existing vessels, is a multistep process regulated by modulators of angiogenesis. It is essential for various physiological processes, such as embryonic development, chronic inflammation, and wound repair. Dysregulation of angiogenesis causes many diseases, such as cancer, autoimmune diseases, rheumatoid arthritis, cardiovascular disease, and delayed wound healing. However, the number of effective anti-angiogenic drugs is limited. Recent research has focused on identifying potential drug candidates from natural sources. For example, marine natural products have been shown to have anti-cancer, anti-oxidant, anti-inflammatory, antiviral, and wound- healing effects. Thus, this study aimed to describe the angiogenesis inhibitory effect of Hizikia fusiforms (brown algae) extract. The hexane extract of H. fusiformis has shown inhibitory effects on in vitro angiogenesis assays, such as cell migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs). The hexane extract of H. fusiformis (HFH) inhibited in vivo angiogenesis in a mouse Matrigel gel plug assay. In addition, the protein expression of vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/extracellular signal kinase, and AKT serine/threonine kinase 1 decreased following treatment with H. fusiformis extracts. Our results demonstrated that the hexane extract of H. fusiformis (HFH) inhibits angiogenesis in vitro and in vivo.
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