Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on In Vitro Screening and In Vivo Evaluation of Zingiber officinale Rosc. Extracts
DC Field | Value | Language |
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dc.contributor.author | Min, Su Ji | - |
dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Seo, Chang-Seob | - |
dc.contributor.author | Choi, You-Kyong | - |
dc.date.accessioned | 2023-10-19T10:40:32Z | - |
dc.date.available | 2023-10-19T10:40:32Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89387 | - |
dc.description.abstract | Ten traditional herbal extracts effective against diarrhea, infectious diseases, and bacterial activity were selected and analyzed for Peyer's patch cell-mediated intestinal immunomodulatory activity in vitro and in vivo. Among the 10 herbal extracts, Zingiber officinale Rosc. (ZO) extract induced the highest secretion of immunoglobulin A (IgA) and granulocyte macrophage colony-stimulating factor (GM-CSF) in the cells of Peyer's patches. Furthermore, animal experiments showed that IA production was enhanced with the oral administration of ZO extract (100 mg/kg and 300 mg/kg) for 10 days. In addition, 6-, 8-, 10-gingerol, and 6-, 8-, 10-shogaol, the six major index compounds of ZO extract, were analyzed using HPLC. Our study findings confirm the intestinal immunomodulatory activity of ZO extract and lay a strong foundation for future analytical studies aimed at determining the active components of ZO extracts. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on In Vitro Screening and In Vivo Evaluation of Zingiber officinale Rosc. Extracts | - |
dc.type | Article | - |
dc.identifier.wosid | 001076937800001 | - |
dc.identifier.doi | 10.3390/molecules28186743 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.28, no.18 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85172795286 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 28 | - |
dc.citation.number | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | IgA | - |
dc.subject.keywordAuthor | intestinal immune modulation | - |
dc.subject.keywordAuthor | Peyer's patch | - |
dc.subject.keywordAuthor | Zingiber officinale Rosc. | - |
dc.subject.keywordPlus | T-CELL-ACTIVATION | - |
dc.subject.keywordPlus | PEYERS-PATCHES | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | IGA | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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