Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on In Vitro Screening and In Vivo Evaluation of Zingiber officinale Rosc. Extractsopen access
- Authors
- Min, Su Ji; Kim, Sung Jin; Park, Jun Yeon; Seo, Chang-Seob; Choi, You-Kyong
- Issue Date
- Sep-2023
- Publisher
- MDPI
- Keywords
- IgA; intestinal immune modulation; Peyer's patch; Zingiber officinale Rosc.
- Citation
- MOLECULES, v.28, no.18
- Journal Title
- MOLECULES
- Volume
- 28
- Number
- 18
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89387
- DOI
- 10.3390/molecules28186743
- ISSN
- 1420-3049
1420-3049
- Abstract
- Ten traditional herbal extracts effective against diarrhea, infectious diseases, and bacterial activity were selected and analyzed for Peyer's patch cell-mediated intestinal immunomodulatory activity in vitro and in vivo. Among the 10 herbal extracts, Zingiber officinale Rosc. (ZO) extract induced the highest secretion of immunoglobulin A (IgA) and granulocyte macrophage colony-stimulating factor (GM-CSF) in the cells of Peyer's patches. Furthermore, animal experiments showed that IA production was enhanced with the oral administration of ZO extract (100 mg/kg and 300 mg/kg) for 10 days. In addition, 6-, 8-, 10-gingerol, and 6-, 8-, 10-shogaol, the six major index compounds of ZO extract, were analyzed using HPLC. Our study findings confirm the intestinal immunomodulatory activity of ZO extract and lay a strong foundation for future analytical studies aimed at determining the active components of ZO extracts.
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Collections - 한의과대학 > 한의학과 > 1. Journal Articles
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