Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death
DC Field | Value | Language |
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dc.contributor.author | Choi, Yeram | - |
dc.contributor.author | Park, Sangkyu | - |
dc.contributor.author | Lee, Seul | - |
dc.contributor.author | Shin, Ha-Eun | - |
dc.contributor.author | Kwon, Sangil | - |
dc.contributor.author | Choi, Jun-Kyu | - |
dc.contributor.author | Lee, Myeong-Heon | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Lee, Younghee | - |
dc.date.accessioned | 2023-10-24T01:40:40Z | - |
dc.date.available | 2023-10-24T01:40:40Z | - |
dc.date.created | 2023-09-28 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89416 | - |
dc.description.abstract | Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among women wordlwide. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment strategies are needed. In this study, we investigated the anti-cancer effect of synthetic homoisoflavane derivatives of cremastranone on breast cancer cells. Homoisoflavane derivatives, SH-17059 and SH-19021, reduced cell proliferation through G2/M cell cycle arrest and induced caspase-independent cell death. These compounds increased heme oxygenase-1 (HO-1) and 5-aminolevulinic acid synthase 1 (ALAS1), suggesting downregulation of heme. They also induced reactive oxygen species (ROS) generation and lipid peroxidation. Furthermore, they reduced expression of glutathione peroxidase 4 (GPX4). Therefore, we suggest that the SH-17059 and SH-19021 induced the caspase-independent cell death through the accumulation of iron from heme degradation, and the ferroptosis might be one of the potential candidates for caspase-independent cell death. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국응용약물학회 | - |
dc.relation.isPartOf | Biomolecules & Therapeutics | - |
dc.title | Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001072287500005 | - |
dc.identifier.doi | 10.4062/biomolther.2023.057 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.31, no.5, pp.526 - 535 | - |
dc.identifier.kciid | ART002988369 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85170579851 | - |
dc.citation.endPage | 535 | - |
dc.citation.startPage | 526 | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 31 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Seul | - |
dc.contributor.affiliatedAuthor | Kwon, Sangil | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Cremastranone | - |
dc.subject.keywordAuthor | Homoisoflavane | - |
dc.subject.keywordAuthor | Cell cycle arrest | - |
dc.subject.keywordAuthor | Caspase-independent cell death | - |
dc.subject.keywordAuthor | Anti-cancer | - |
dc.subject.keywordPlus | D1 OVEREXPRESSION | - |
dc.subject.keywordPlus | FERROPTOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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