Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Deathopen access
- Authors
- Choi, Yeram; Park, Sangkyu; Lee, Seul; Shin, Ha-Eun; Kwon, Sangil; Choi, Jun-Kyu; Lee, Myeong-Heon; Seo, Seung-Yong; Lee, Younghee
- Issue Date
- Sep-2023
- Publisher
- 한국응용약물학회
- Keywords
- Breast cancer; Cremastranone; Homoisoflavane; Cell cycle arrest; Caspase-independent cell death; Anti-cancer
- Citation
- Biomolecules & Therapeutics, v.31, no.5, pp.526 - 535
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 31
- Number
- 5
- Start Page
- 526
- End Page
- 535
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89416
- DOI
- 10.4062/biomolther.2023.057
- ISSN
- 1976-9148
- Abstract
- Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among women wordlwide. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment strategies are needed. In this study, we investigated the anti-cancer effect of synthetic homoisoflavane derivatives of cremastranone on breast cancer cells.
Homoisoflavane derivatives, SH-17059 and SH-19021, reduced cell proliferation through G2/M cell cycle arrest and induced caspase-independent cell death. These compounds increased heme oxygenase-1 (HO-1) and 5-aminolevulinic acid synthase 1 (ALAS1), suggesting downregulation of heme. They also induced reactive oxygen species (ROS) generation and lipid peroxidation.
Furthermore, they reduced expression of glutathione peroxidase 4 (GPX4). Therefore, we suggest that the SH-17059 and SH-19021 induced the caspase-independent cell death through the accumulation of iron from heme degradation, and the ferroptosis might be one of the potential candidates for caspase-independent cell death.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89416)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.