A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Won, Young-Woong | - |
dc.contributor.author | Kang, Jin-Hyoung | - |
dc.contributor.author | Kwon, Jung Hye | - |
dc.contributor.author | Koo, Dong-Hoe | - |
dc.contributor.author | Kang, Jung Hun | - |
dc.contributor.author | Maeng, Chi Hoon | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Oh, Sung Yong | - |
dc.contributor.author | Lee, Dae-Won | - |
dc.contributor.author | Sohn, Joohyuk | - |
dc.contributor.author | Oh, So Yeon | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Koh, Su-Jin | - |
dc.contributor.author | Lee, Keun Seok | - |
dc.contributor.author | Kim, Chan-Kyu | - |
dc.contributor.author | Kim, Ji-Yeon | - |
dc.contributor.author | Ji, Jun Ho | - |
dc.contributor.author | Kim, Sung-Bae | - |
dc.contributor.author | Ha, Joo Young | - |
dc.contributor.author | Kim, Ho Young | - |
dc.date.accessioned | 2023-12-15T15:09:48Z | - |
dc.date.available | 2023-12-15T15:09:48Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.issn | 2005-9256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89575 | - |
dc.description.abstract | Purpose Several previous studies and case reports have reported ethanol-induced symptoms in patients receiving anticancer drugs containing ethanol. Most docetaxel formulations contain ethanol as a solvent. However, there are insufficient data on ethanol-induced symptoms when docetaxel-containing ethanol is administered. The primary purpose of this study was to investigate the frequency and pattern of ethanol-induced symptoms during and after docetaxel administration. The secondary purpose was to explore the risk factors for ethanol-induced symptoms.Materials and Methods This was a prospective, multicenter, observational study. The participants filled out ethanol-induced symptom questionnaire on the day of chemotherapy and the following day.Results Data from 451 patients were analyzed. The overall occurrence rate of ethanol-induced symptoms was 44.3% (200/451 patients). The occurrence rate of facial flushing was highest at 19.7% (89/451 patients), followed by nausea in 18.2% (82/451 patients), and dizziness in 17.5% (79/451 patients). Although infrequent, unsteady walking and impaired balance occurred in 4.2% and 3.3% of patients, respectively. Female sex, presence of underlying disease, younger age, docetaxel dose, and docetaxel-containing ethanol amount were significantly associated with the occurrence of ethanol-induced symptoms.Conclusion The occurrence of ethanol-induced symptoms was not low in patients receiving docetaxel-containing ethanol. Physicians need to pay more attention to the occurrence of ethanol-induced symptoms and prescribe ethanol-free or low-ethanol-containing formulations to high-risk patients. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.title | A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapy | - |
dc.type | Article | - |
dc.identifier.wosid | 001091828000002 | - |
dc.identifier.doi | 10.4143/crt.2022.1565 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.55, no.4, pp 1096 - 1103 | - |
dc.identifier.kciid | ART003005571 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85174642494 | - |
dc.citation.endPage | 1103 | - |
dc.citation.startPage | 1096 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 55 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Ethanol | - |
dc.subject.keywordAuthor | Docetaxel | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordPlus | ALCOHOL METABOLISM | - |
dc.subject.keywordPlus | GENDER-DIFFERENCES | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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