A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapyopen access
- Authors
- Won, Young-Woong; Kang, Jin-Hyoung; Kwon, Jung Hye; Koo, Dong-Hoe; Kang, Jung Hun; Maeng, Chi Hoon; Ahn, Hee Kyung; Oh, Sung Yong; Lee, Dae-Won; Sohn, Joohyuk; Oh, So Yeon; Lee, Kyung Hee; Koh, Su-Jin; Lee, Keun Seok; Kim, Chan-Kyu; Kim, Ji-Yeon; Ji, Jun Ho; Kim, Sung-Bae; Ha, Joo Young; Kim, Ho Young
- Issue Date
- Oct-2023
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Ethanol; Docetaxel; Chemotherapy
- Citation
- CANCER RESEARCH AND TREATMENT, v.55, no.4, pp 1096 - 1103
- Pages
- 8
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 55
- Number
- 4
- Start Page
- 1096
- End Page
- 1103
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89575
- DOI
- 10.4143/crt.2022.1565
- ISSN
- 1598-2998
2005-9256
- Abstract
- Purpose Several previous studies and case reports have reported ethanol-induced symptoms in patients receiving anticancer drugs containing ethanol. Most docetaxel formulations contain ethanol as a solvent. However, there are insufficient data on ethanol-induced symptoms when docetaxel-containing ethanol is administered. The primary purpose of this study was to investigate the frequency and pattern of ethanol-induced symptoms during and after docetaxel administration. The secondary purpose was to explore the risk factors for ethanol-induced symptoms.Materials and Methods This was a prospective, multicenter, observational study. The participants filled out ethanol-induced symptom questionnaire on the day of chemotherapy and the following day.Results Data from 451 patients were analyzed. The overall occurrence rate of ethanol-induced symptoms was 44.3% (200/451 patients). The occurrence rate of facial flushing was highest at 19.7% (89/451 patients), followed by nausea in 18.2% (82/451 patients), and dizziness in 17.5% (79/451 patients). Although infrequent, unsteady walking and impaired balance occurred in 4.2% and 3.3% of patients, respectively. Female sex, presence of underlying disease, younger age, docetaxel dose, and docetaxel-containing ethanol amount were significantly associated with the occurrence of ethanol-induced symptoms.Conclusion The occurrence of ethanol-induced symptoms was not low in patients receiving docetaxel-containing ethanol. Physicians need to pay more attention to the occurrence of ethanol-induced symptoms and prescribe ethanol-free or low-ethanol-containing formulations to high-risk patients.
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