Kaempferol Alleviates Mitochondrial Damage by Reducing Mitochondrial Reactive Oxygen Species Production in Lipopolysaccharide-Induced Prostate Organoids
DC Field | Value | Language |
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dc.contributor.author | Lee, Myeong Joon | - |
dc.contributor.author | Cho, Yeonoh | - |
dc.contributor.author | Hwang, Yujin | - |
dc.contributor.author | Jo, Youngheun | - |
dc.contributor.author | Kim, Yeon-Gu | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Lee, Jong Hun | - |
dc.date.accessioned | 2023-12-15T15:09:51Z | - |
dc.date.available | 2023-12-15T15:09:51Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2304-8158 | - |
dc.identifier.issn | 2304-8158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89579 | - |
dc.description.abstract | Common prostate diseases such as prostatitis and benign prostatic hyperplasia (BPH) have a high incidence at any age. Cellular stresses, such as reactive oxygen species (ROS) and chronic inflammation, are implicated in prostate enlargement and cancer progression and development. Kaempferol is a flavonoid found in abundance in various plants, including broccoli and spinach, and has been reported to exhibit positive biological activities, such as antioxidant and anti-inflammatory properties. In the present study, we introduced prostate organoids to investigate the protective effects of kaempferol against various cellular stresses. The levels of COX-2, iNOS, p-I kappa B, a pro-inflammatory cytokine, and ROS were increased by LPS treatment but reversed by kaempferol treatment. Kaempferol activated the nuclear factor erythroid 2-related factor 2(Nrf2)-related pathway and enhanced the mitochondrial quality control proteins PGC-1 alpha, PINK1, Parkin, and Beclin. The increase in mitochondrial ROS and oxygen consumption induced by LPS was stabilized by kaempferol treatment. First, our study used prostate organoids as a novel evaluation platform. Secondly, it was demonstrated that kaempferol could alleviate the mitochondrial damage in LPS-induced induced prostate organoids by reducing the production of mitochondrial ROS. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Kaempferol Alleviates Mitochondrial Damage by Reducing Mitochondrial Reactive Oxygen Species Production in Lipopolysaccharide-Induced Prostate Organoids | - |
dc.type | Article | - |
dc.identifier.wosid | 001095359200001 | - |
dc.identifier.doi | 10.3390/foods12203836 | - |
dc.identifier.bibliographicCitation | FOODS, v.12, no.20 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85175194301 | - |
dc.citation.title | FOODS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 20 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | organoid | - |
dc.subject.keywordAuthor | kaempferol | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | mitophagy | - |
dc.subject.keywordAuthor | mitochondrial homeostasis | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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