Kaempferol Alleviates Mitochondrial Damage by Reducing Mitochondrial Reactive Oxygen Species Production in Lipopolysaccharide-Induced Prostate Organoidsopen access
- Authors
- Lee, Myeong Joon; Cho, Yeonoh; Hwang, Yujin; Jo, Youngheun; Kim, Yeon-Gu; Lee, Seung Hwan; Lee, Jong Hun
- Issue Date
- Oct-2023
- Publisher
- MDPI
- Keywords
- organoid; kaempferol; anti-inflammation; antioxidant; ROS; mitophagy; mitochondrial homeostasis
- Citation
- FOODS, v.12, no.20
- Journal Title
- FOODS
- Volume
- 12
- Number
- 20
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89579
- DOI
- 10.3390/foods12203836
- ISSN
- 2304-8158
2304-8158
- Abstract
- Common prostate diseases such as prostatitis and benign prostatic hyperplasia (BPH) have a high incidence at any age. Cellular stresses, such as reactive oxygen species (ROS) and chronic inflammation, are implicated in prostate enlargement and cancer progression and development. Kaempferol is a flavonoid found in abundance in various plants, including broccoli and spinach, and has been reported to exhibit positive biological activities, such as antioxidant and anti-inflammatory properties. In the present study, we introduced prostate organoids to investigate the protective effects of kaempferol against various cellular stresses. The levels of COX-2, iNOS, p-I kappa B, a pro-inflammatory cytokine, and ROS were increased by LPS treatment but reversed by kaempferol treatment. Kaempferol activated the nuclear factor erythroid 2-related factor 2(Nrf2)-related pathway and enhanced the mitochondrial quality control proteins PGC-1 alpha, PINK1, Parkin, and Beclin. The increase in mitochondrial ROS and oxygen consumption induced by LPS was stabilized by kaempferol treatment. First, our study used prostate organoids as a novel evaluation platform. Secondly, it was demonstrated that kaempferol could alleviate the mitochondrial damage in LPS-induced induced prostate organoids by reducing the production of mitochondrial ROS.
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