Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Yun | - |
dc.contributor.author | Hong, Nayoung | - |
dc.contributor.author | Park, Sehyeon | - |
dc.contributor.author | Ham, Seok Won | - |
dc.contributor.author | Kim, Eun-Jung | - |
dc.contributor.author | Kim, Sung-Ok | - |
dc.contributor.author | Jang, Junseok | - |
dc.contributor.author | Kim, Yoonji | - |
dc.contributor.author | Kim, Jun-Kyum | - |
dc.contributor.author | Kim, Sung-Chan | - |
dc.contributor.author | Park, Jong-Whi | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2023-12-27T01:00:17Z | - |
dc.date.available | 2023-12-27T01:00:17Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89827 | - |
dc.description.abstract | Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain translocates to the nucleus, where it functions as a transcriptional cofactor. Previously, we showed that JAG1 intracellular domain (JICD1) forms a protein complex with DDX17/SMAD3/TGIF2. However, the molecular mechanisms underlying JICD1-mediated tumor aggressiveness remains unclear. Here, we demonstrate that JICD1 enhances the invasive phenotypes of glioblastoma cells by transcriptionally activating epithelial-to-mesenchymal transition (EMT)-related genes, especially TWIST1. The inhibition of TWIST1 reduced JICD1-driven tumor aggressiveness. Although SMAD3 is an important component of transforming growth factor (TGF)-β signaling, the JICD1/SMAD3 transcriptional complex was shown to govern brain tumor invasion independent of TGF-β signaling. Moreover, JICD1-TWIST1-MMP2 and MMP9 axes were significantly correlated with clinical outcome of glioblastoma patients. Collectively, we identified the JICD1/SMAD3-TWIST1 axis as a novel inducer of invasive phenotypes in cancer cells. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion | - |
dc.type | Article | - |
dc.identifier.wosid | 001124117500004 | - |
dc.identifier.doi | 10.1038/s41419-023-06356-0 | - |
dc.identifier.bibliographicCitation | Cell Death and Disease, v.14, no.12 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85179645134 | - |
dc.citation.title | Cell Death and Disease | - |
dc.citation.volume | 14 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | PROTEIN-PROTEIN INTERACTIONS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | NOTCH LIGANDS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SMAD3 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SECRETASE | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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