Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion
- Authors
- Kim, Jung Yun; Hong, Nayoung; Park, Sehyeon; Ham, Seok Won; Kim, Eun-Jung; Kim, Sung-Ok; Jang, Junseok; Kim, Yoonji; Kim, Jun-Kyum; Kim, Sung-Chan; Park, Jong-Whi; Kim, Hyunggee
- Issue Date
- Dec-2023
- Publisher
- Nature Publishing Group
- Citation
- Cell Death and Disease, v.14, no.12
- Journal Title
- Cell Death and Disease
- Volume
- 14
- Number
- 12
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89827
- DOI
- 10.1038/s41419-023-06356-0
- ISSN
- 2041-4889
- Abstract
- Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain translocates to the nucleus, where it functions as a transcriptional cofactor. Previously, we showed that JAG1 intracellular domain (JICD1) forms a protein complex with DDX17/SMAD3/TGIF2. However, the molecular mechanisms underlying JICD1-mediated tumor aggressiveness remains unclear. Here, we demonstrate that JICD1 enhances the invasive phenotypes of glioblastoma cells by transcriptionally activating epithelial-to-mesenchymal transition (EMT)-related genes, especially TWIST1. The inhibition of TWIST1 reduced JICD1-driven tumor aggressiveness. Although SMAD3 is an important component of transforming growth factor (TGF)-β signaling, the JICD1/SMAD3 transcriptional complex was shown to govern brain tumor invasion independent of TGF-β signaling. Moreover, JICD1-TWIST1-MMP2 and MMP9 axes were significantly correlated with clinical outcome of glioblastoma patients. Collectively, we identified the JICD1/SMAD3-TWIST1 axis as a novel inducer of invasive phenotypes in cancer cells.
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