A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dutta, Sayan Deb | - |
dc.contributor.author | Ganguly, Keya | - |
dc.contributor.author | Hexiu, Jin | - |
dc.contributor.author | Randhawa, Aayushi | - |
dc.contributor.author | Moniruzzaman, Md | - |
dc.contributor.author | Lim, Ki-Taek | - |
dc.date.accessioned | 2024-01-27T06:00:19Z | - |
dc.date.available | 2024-01-27T06:00:19Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.issn | 1616-5195 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90233 | - |
dc.description.abstract | One of the significant challenges in bone tissue engineering (BTE) is the healing of traumatic tissue defects owing to the recruitment of local infection and delayed angiogenesis. Herein, a 3D printable multi-functional hydrogel composing polyphenolic carbon quantum dots (CQDs, 100 mu g mL(-1)) and gelatin methacryloyl (GelMA, 12 wt%) is reported for robust angiogenesis, bone regeneration and anti-tumor therapy. The CQDs are synthesized from a plant-inspired bioactive molecule, 1, 3, 5-trihydroxybenzene. The 3D printed GelMA-CQDs hydrogels display typical shear-thinning behavior with excellent printability. The fabricated hydrogel displayed M2 polarization of macrophage (Raw 264.7) cells via enhancing anti-inflammatory genes (e.g., IL-4 and IL10), and induced angiogenesis and osteogenesis of human bone mesenchymal stem cells (hBMSCs). The bioprinted hBMSCs are able to produce vessel-like structures after 14 d of incubation. Furthermore, the 3D printed hydrogel scaffolds also show remarkable near infra-red (NIR) responsive properties under 808 nm NIR light (1.0 W cm(-2)) irradiation with controlled release of antitumor drugs (approximate to 49%) at pH 6.5, and thereby killing the osteosarcoma cells. Therefore, it is anticipated that the tissue regeneration and healing ability with therapeutic potential of the GelMA-CQDs scaffolds may provide a promising alternative for traumatic tissue regeneration via augmenting angiogenesis and accelerated immunomodulation. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation | - |
dc.type | Article | - |
dc.identifier.wosid | 000980193600001 | - |
dc.identifier.doi | 10.1002/mabi.202300096 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.23, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85156095259 | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 23 | - |
dc.citation.number | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | multifunctional hydrogel | - |
dc.subject.keywordAuthor | osteoimmunity | - |
dc.subject.keywordAuthor | polyphenolic carbon quantum dots | - |
dc.subject.keywordAuthor | tumor ablation | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.