A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation
- Authors
- Dutta, Sayan Deb; Ganguly, Keya; Hexiu, Jin; Randhawa, Aayushi; Moniruzzaman, Md; Lim, Ki-Taek
- Issue Date
- Sep-2023
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- anti-inflammatory; multifunctional hydrogel; osteoimmunity; polyphenolic carbon quantum dots; tumor ablation
- Citation
- MACROMOLECULAR BIOSCIENCE, v.23, no.9
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 23
- Number
- 9
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90233
- DOI
- 10.1002/mabi.202300096
- ISSN
- 1616-5187
1616-5195
- Abstract
- One of the significant challenges in bone tissue engineering (BTE) is the healing of traumatic tissue defects owing to the recruitment of local infection and delayed angiogenesis. Herein, a 3D printable multi-functional hydrogel composing polyphenolic carbon quantum dots (CQDs, 100 mu g mL(-1)) and gelatin methacryloyl (GelMA, 12 wt%) is reported for robust angiogenesis, bone regeneration and anti-tumor therapy. The CQDs are synthesized from a plant-inspired bioactive molecule, 1, 3, 5-trihydroxybenzene. The 3D printed GelMA-CQDs hydrogels display typical shear-thinning behavior with excellent printability. The fabricated hydrogel displayed M2 polarization of macrophage (Raw 264.7) cells via enhancing anti-inflammatory genes (e.g., IL-4 and IL10), and induced angiogenesis and osteogenesis of human bone mesenchymal stem cells (hBMSCs). The bioprinted hBMSCs are able to produce vessel-like structures after 14 d of incubation. Furthermore, the 3D printed hydrogel scaffolds also show remarkable near infra-red (NIR) responsive properties under 808 nm NIR light (1.0 W cm(-2)) irradiation with controlled release of antitumor drugs (approximate to 49%) at pH 6.5, and thereby killing the osteosarcoma cells. Therefore, it is anticipated that the tissue regeneration and healing ability with therapeutic potential of the GelMA-CQDs scaffolds may provide a promising alternative for traumatic tissue regeneration via augmenting angiogenesis and accelerated immunomodulation.
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