카무트밀 효소 식이가 Dextran Sulfate Sodium으로 유발한 대장염 마우스에 미치는 효과Effects of Kamut Wheat Enzyme Diet on Dextran Sulfate Sodium-induced Colitis Mice
- Other Titles
- Effects of Kamut Wheat Enzyme Diet on Dextran Sulfate Sodium-induced Colitis Mice
- Authors
- 길범주; 백채윤; 이준이; 황예슬; 최여진; 손주희; 유미애; 이동훈; 이동헌
- Issue Date
- Jan-2024
- Publisher
- 대한본초학회
- Keywords
- Dextran Sulfate Sodium; Ulcerative Colitis; Kamut Wheat Enzyme; Anti-Inflammatory Effect
- Citation
- 대한본초학회지, v.39, no.1, pp 31 - 38
- Pages
- 8
- Journal Title
- 대한본초학회지
- Volume
- 39
- Number
- 1
- Start Page
- 31
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90242
- DOI
- 10.6116/kjh.2024.39.1.31
- ISSN
- 1229-1765
2288-7199
- Abstract
- Objectives : Ulcerative colitis is a chronic recurrent inflammatory disease of the gastrointestinal tract. However, there are some drawbacks to long-term drug therapy such as the risk of opportunistic infections. Recently, there was an increasing interest on the use of khorasan Kamut wheat because of their higher value of selenium and fiber than modern wheat. The present study was aimed to investigate the effect of Kamut brand wheat enzyme (Kamut WE) diet on colon health in dextran sulfate sodium (DSS)-induced colitis mice.
Methods : Female C57BL/6J mice were divided into 6 groups. (1) normal (Water and AIN-93G diet), (2) control (1.25% DSS and AIN-93G diet), (3) Kamut WE (1.25% DSS and Kamut WE diet), (4) normal (Water and AIN-93G diet), (5) control (2.50% DSS and AIN-93G diet), (6) Kamut WE (2.50% DSS and Kamut WE diet). Dietary intake, body weight change, disease activity index (DAI), colon length and spleen weight were monitored.
Results : Kamut WE group alleviated colitis symptom, including dietary intake loss, DAI (weight loss, loose stools, bleeding), colon length shortening and spleen swelling. Further, Kamut WE diets showed a significant effect against pathological damage by the increased colon length, decreased DAI and spleen weight in DSS 1.25% as well as DSS 2.50%.
Conclusions : Our study provides evidence that Kamut WE diet increased colon length, decreased DAI and spleen weight in intestinal inflammation.
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