Treadmill exercise ameliorates chemotherapy-induced memory impairment through Wnt/β-catenin signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Sang-Seo | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Kim, Bo-Kyun | - |
dc.contributor.author | Shin, Mal-Soon | - |
dc.contributor.author | Jeong, Hyun-Tae | - |
dc.contributor.author | Park, Jong-Suk | - |
dc.contributor.author | Kim, Tae-Woon | - |
dc.date.accessioned | 2024-02-15T02:30:19Z | - |
dc.date.available | 2024-02-15T02:30:19Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1976-6319 | - |
dc.identifier.issn | 2288-1778 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90420 | - |
dc.description.abstract | Doxorubicin (DOX) is a widely used chemotherapy drug for various cancers and it is known to induce cognitive impairment. The aim of this study was to investigate the effect of treadmill exercise on chemotherapy-induced memory impairment. We assessed whether DOX affects inflammation, mitochondrial Ca2+ retention capacity, and Wnt/β-catenin signaling. Male Sprague-Dawley rats were divided into control group, exercise group, DOX-injection group, and DOX-injection and exercise group. To create a DOX-induced memory impairment model, animals were injected intraperitoneally with DOX (2 mg/kg) dissolved in saline solution once a week for 4 weeks. Treadmill exercise was performed once a day, 5 days a week, for 8 consecutive weeks. Short-term memory was determined using the step-down avoidance test. Western blot was performed for the proinflammatory cytokines, Wnt/β-catenin signaling, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) in the hippocampus. Mitochondrial Ca2+ retention capacity in the hippocampus was also measured. DOX-injection rats showed deterioration of short-term memory along with decreased expression of BDNF and TrkB in the hippocampus. Levels of the proinflammatory cytokines, tumor necrosis factor-α and interleukin-6, were increased in the DOX-injection rats. Wnt/β-catenin signaling was activat-ed and mitochondrial Ca2+ retention capacity was decreased in the DOX-injection rats. However, treadmill exercise alleviated short-term memory impairment, decreased proinflammatory cytokines, increased BDNF and TrkB expression, and enhanced mitochondrial Ca2+ retention capacity. Treadmill exercise restorated Wnt/β-catenin signaling pathway. This study demonstrated that treadmill exercise can be used for patients undergoing chemotherapy with DOX. © 2023 Korean Society of Exercise Rehabilitation | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Exercise Rehabilitation | - |
dc.title | Treadmill exercise ameliorates chemotherapy-induced memory impairment through Wnt/β-catenin signaling pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 001165063300005 | - |
dc.identifier.doi | 10.12965/jer.2346594.297 | - |
dc.identifier.bibliographicCitation | Journal of Exercise Rehabilitation, v.19, no.6, pp 314 - 319 | - |
dc.identifier.kciid | ART003026187 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85184172987 | - |
dc.citation.endPage | 319 | - |
dc.citation.startPage | 314 | - |
dc.citation.title | Journal of Exercise Rehabilitation | - |
dc.citation.volume | 19 | - |
dc.citation.number | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | Mitochondrial Ca2+ retention capacity | - |
dc.subject.keywordAuthor | Proinflammatory cytokine | - |
dc.subject.keywordAuthor | Short-term memory | - |
dc.subject.keywordAuthor | Treadmill exercise | - |
dc.subject.keywordAuthor | Wnt/β-catenin signaling | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | COGNITIVE FUNCTION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | PLASMA | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
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