Treadmill exercise ameliorates chemotherapy-induced memory impairment through Wnt/β-catenin signaling pathway
- Authors
- Park, Sang-Seo; Kim, Sang-Hoon; Kim, Bo-Kyun; Shin, Mal-Soon; Jeong, Hyun-Tae; Park, Jong-Suk; Kim, Tae-Woon
- Issue Date
- Dec-2023
- Publisher
- Korean Society of Exercise Rehabilitation
- Keywords
- Doxorubicin; Mitochondrial Ca2+ retention capacity; Proinflammatory cytokine; Short-term memory; Treadmill exercise; Wnt/β-catenin signaling
- Citation
- Journal of Exercise Rehabilitation, v.19, no.6, pp 314 - 319
- Pages
- 6
- Journal Title
- Journal of Exercise Rehabilitation
- Volume
- 19
- Number
- 6
- Start Page
- 314
- End Page
- 319
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90420
- DOI
- 10.12965/jer.2346594.297
- ISSN
- 1976-6319
2288-1778
- Abstract
- Doxorubicin (DOX) is a widely used chemotherapy drug for various cancers and it is known to induce cognitive impairment. The aim of this study was to investigate the effect of treadmill exercise on chemotherapy-induced memory impairment. We assessed whether DOX affects inflammation, mitochondrial Ca2+ retention capacity, and Wnt/β-catenin signaling. Male Sprague-Dawley rats were divided into control group, exercise group, DOX-injection group, and DOX-injection and exercise group. To create a DOX-induced memory impairment model, animals were injected intraperitoneally with DOX (2 mg/kg) dissolved in saline solution once a week for 4 weeks. Treadmill exercise was performed once a day, 5 days a week, for 8 consecutive weeks. Short-term memory was determined using the step-down avoidance test. Western blot was performed for the proinflammatory cytokines, Wnt/β-catenin signaling, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) in the hippocampus. Mitochondrial Ca2+ retention capacity in the hippocampus was also measured. DOX-injection rats showed deterioration of short-term memory along with decreased expression of BDNF and TrkB in the hippocampus. Levels of the proinflammatory cytokines, tumor necrosis factor-α and interleukin-6, were increased in the DOX-injection rats. Wnt/β-catenin signaling was activat-ed and mitochondrial Ca2+ retention capacity was decreased in the DOX-injection rats. However, treadmill exercise alleviated short-term memory impairment, decreased proinflammatory cytokines, increased BDNF and TrkB expression, and enhanced mitochondrial Ca2+ retention capacity. Treadmill exercise restorated Wnt/β-catenin signaling pathway. This study demonstrated that treadmill exercise can be used for patients undergoing chemotherapy with DOX. © 2023 Korean Society of Exercise Rehabilitation
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