Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammationopen access
- Authors
- Min, Byeong Hyun; Devi, Shivani; Kwon, Goo Hyun; Gupta, Haripriya; Jeong, Jin-Ju; Sharma, Satya Priya; Won, Sung-Min; Oh, Ki-Kwang; Yoon, Sang Jun; Park, Hee Jin; Eom, Jung A.; Jeong, Min Kyo; Hyun, Ji Ye; Stalin, Nattan; Park, Tae-Sik; Choi, Jieun; Lee, Do Yup; Han, Sang Hak; Kim, Dong Joon; Suk, Ki Tae
- Issue Date
- Jun-2024
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Metabolic dysfunction-associated steatotic liver disease; indole; metabolite; gut microbiome; Bifidobacterium
- Citation
- GUT MICROBES, v.16, no.1
- Journal Title
- GUT MICROBES
- Volume
- 16
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90487
- DOI
- 10.1080/19490976.2024.2307568
- ISSN
- 1949-0976
1949-0984
- Abstract
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence has increased worldwide in recent years. Additionally, there is a close relationship between MASLD and gut microbiota-derived metabolites. However, the mechanisms of MASLD and its metabolites are still unclear. We demonstrated decreased indole-3-propionic acid (IPA) and indole-3-acetic acid (IAA) in the feces of patients with hepatic steatosis compared to healthy controls. Here, IPA and IAA administration ameliorated hepatic steatosis and inflammation in an animal model of WD-induced MASLD by suppressing the NF-kappa B signaling pathway through a reduction in endotoxin levels and inactivation of macrophages. Bifidobacterium bifidum metabolizes tryptophan to produce IAA, and B. bifidum effectively prevents hepatic steatosis and inflammation through the production of IAA. Our study demonstrates that IPA and IAA derived from the gut microbiota have novel preventive or therapeutic potential for MASLD treatment.
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