A Wearable ECG Monitoring System Using Microneedle Electrodes for Small Animals
- Authors
- Kim, Chaehyun; Jang, Ahram; Kim, Sebin; Cho, Sungbo; Lee, Donghun; Kim, Young-Joon
- Issue Date
- Sep-2023
- Publisher
- Institute of Electrical and Electronics Engineers Inc.
- Keywords
- electrocardiogram; microneedle electrode; real-time monitoring; wearable device
- Citation
- IEEE Sensors Journal, v.23, no.18, pp 21873 - 21881
- Pages
- 9
- Journal Title
- IEEE Sensors Journal
- Volume
- 23
- Number
- 18
- Start Page
- 21873
- End Page
- 21881
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90577
- DOI
- 10.1109/JSEN.2023.3300992
- ISSN
- 1530-437X
1558-1748
- Abstract
- The electrocardiogram (ECG) is an effective tool for monitoring various health conditions, and animal studies using ECG have uncovered new information about complex diseases. However, monitoring electrophysio-logical signals in small animals such as mice has been challenging. In this study, we present a simple, minimally invasive, and inexpensive ECG measurement sensory system for mice that offers real-time data acquisition while performing a surgery. We developed a miniaturized, wearable ECG monitoring device that utilizes miniature-sized, rigid metal-type microneedle electrodes with a skin-electrode contact resistivity of 20 kΩ at 10 Hz, which is lower than commercial Ag/AgCl electrodes used in human ECGs. The device, excluding the battery, is less than 50 cubic millimeters in size and amplifies and converts the waveform which is transmitted to a personal cell phone or laptop. We developed a smartphone application to display the real-time ECG waveform and heart rate without the need for additional equipment. The recorded data can be retrieved for further analysis, and the real-time display feature can be used to monitor an animal’s condition during surgery. We validated this method by inducing a photothrombotic stroke in an ICR mouse to study ECG and HR parameters in an animal stroke model. IEEE
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