Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Hwan | - |
dc.contributor.author | Huh, Wonsang | - |
dc.contributor.author | Baek, Ji Yun | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Kim, So Hyeon | - |
dc.contributor.author | Park, Il-Ho | - |
dc.contributor.author | Pyo, Jaesung | - |
dc.contributor.author | Seo, Chang-Seob | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2024-03-08T08:01:32Z | - |
dc.date.available | 2024-03-08T08:01:32Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90585 | - |
dc.description.abstract | Many hangover cure products containing natural ingredients that are also effective against alcohol-related liver damage or improve liver function have recently become available. In addition to curing liver damage, antioxidants, anti-inflammatory agents, and blood ethanol reduction aids are emerging as relief targets that reduce hangover symptoms. We investigated the ameliorating effect of WON-21 herbal medicinal products by studying the mixing ratio of oriental medicine concept with respect to antioxidant potential, anti-inflammation, and aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) enzyme activities. WON-21 and its components exerted antioxidant and anti-inflammatory effects. Rutin, taxifolin, and quercetin showed superior antioxidant effects compared to the other components. WON-12 effectively reduced iNOS and COX-2 in LPS-stimulated macrophages. Quercetin and apigenin were 2 compounds effective for the inhibition of iNOS and COX-2. WON-21 and quercetin also significantly increased the activities of ALDH and ADH enzymes in a concentration-dependent manner. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER SINGAPORE PTE LTD | - |
dc.title | Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes | - |
dc.type | Article | - |
dc.identifier.wosid | 001079527100001 | - |
dc.identifier.doi | 10.1186/s13765-023-00800-7 | - |
dc.identifier.bibliographicCitation | APPLIED BIOLOGICAL CHEMISTRY, v.66, no.1, pp 1 - 14 | - |
dc.identifier.kciid | ART002981741 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85165315798 | - |
dc.citation.endPage | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 66 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.publisher.location | 싱가폴 | - |
dc.subject.keywordAuthor | Hangover | - |
dc.subject.keywordAuthor | Blood ethanol | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordPlus | N-ACETYLCYSTEINE | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | NAUSEA | - |
dc.subject.keywordPlus | HYDRATION | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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