Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymesopen access
- Authors
- Lee, Ji Hwan; Huh, Wonsang; Baek, Ji Yun; Park, Jun Yeon; Kim, So Hyeon; Park, Il-Ho; Pyo, Jaesung; Seo, Chang-Seob; Kang, Ki Sung
- Issue Date
- Jul-2023
- Publisher
- SPRINGER SINGAPORE PTE LTD
- Keywords
- Hangover; Blood ethanol; Antioxidant; Anti-inflammation
- Citation
- APPLIED BIOLOGICAL CHEMISTRY, v.66, no.1, pp 1 - 14
- Pages
- 14
- Journal Title
- APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 66
- Number
- 1
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90585
- DOI
- 10.1186/s13765-023-00800-7
- ISSN
- 2468-0834
2468-0842
- Abstract
- Many hangover cure products containing natural ingredients that are also effective against alcohol-related liver damage or improve liver function have recently become available. In addition to curing liver damage, antioxidants, anti-inflammatory agents, and blood ethanol reduction aids are emerging as relief targets that reduce hangover symptoms. We investigated the ameliorating effect of WON-21 herbal medicinal products by studying the mixing ratio of oriental medicine concept with respect to antioxidant potential, anti-inflammation, and aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) enzyme activities. WON-21 and its components exerted antioxidant and anti-inflammatory effects. Rutin, taxifolin, and quercetin showed superior antioxidant effects compared to the other components. WON-12 effectively reduced iNOS and COX-2 in LPS-stimulated macrophages. Quercetin and apigenin were 2 compounds effective for the inhibition of iNOS and COX-2. WON-21 and quercetin also significantly increased the activities of ALDH and ADH enzymes in a concentration-dependent manner.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90585)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.