Inflammation-Targeting Mesenchymal Stem Cells Combined with Photothermal Treatment Attenuate Severe Joint Inflammation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Min Jun | - |
dc.contributor.author | Park, Jun-Young | - |
dc.contributor.author | Park, Jun Young | - |
dc.contributor.author | Lim, Su Hyun | - |
dc.contributor.author | Lim, Hyoungsu | - |
dc.contributor.author | Choi, Jin Kyeong | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.contributor.author | Kang, Youn Joo | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.date.accessioned | 2024-03-21T11:00:16Z | - |
dc.date.available | 2024-03-21T11:00:16Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.issn | 1521-4095 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90780 | - |
dc.description.abstract | Current clinical therapeutic efficacy for the treatment of osteo- and rheumatoid-arthritis is obviously limited. Although mesenchymal stem cells (MSCs) are considered as a source of promising regenerative therapy, un-modified or genetically engineered MSCs injected in vivo restrict their clinical utility because of the low drug efficacy and unpredicted side effect, respectively. Herein, a strategy to enhance the migration efficacy of MSCs to inflamed joints via an inflammation-mediated education process is demonstrated. To reinforce the limited anti-inflammatory activity of MSCs, gold nanostar loaded with triamcinolone is conjugated to MSC. Furthermore, near-infrared laser-assisted photothermal therapy (PTT) induced by gold nanostar significantly elevates the anti-inflammatory efficacy of the developed drugs, even in advanced stage arthritis model. An immunological regulation mechanism study of PTT is first suggested in this study; the expression of the interleukin 22 receptor, implicated in the pathogenesis of arthritis, is downregulated in T lymphocytes by PTT, and Th17 differentiation from naïve CD4 T cell is inhibited. Collectively, inflammation-targeting MSCs conjugated with triamcinolone-loaded gold nanostar (Edu-MSCs-AuS-TA) promote the repolarization of macrophages and decrease neutrophil recruitment in joints. In addition, Edu-MSCs-AuS-TA significantly alleviate arthritis-associated pain, improve general locomotor activity, and more importantly, induce cartilage regeneration even for severe stages of arthritis model. © 2023 Wiley-VCH GmbH. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Inflammation-Targeting Mesenchymal Stem Cells Combined with Photothermal Treatment Attenuate Severe Joint Inflammation | - |
dc.type | Article | - |
dc.identifier.wosid | 001129474300001 | - |
dc.identifier.doi | 10.1002/adma.202304333 | - |
dc.identifier.bibliographicCitation | Advanced Materials, v.36, no.11 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85180220559 | - |
dc.citation.title | Advanced Materials | - |
dc.citation.volume | 36 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | arthritis | - |
dc.subject.keywordAuthor | inflammation-educated mesenchymal stem cells | - |
dc.subject.keywordAuthor | membrane conjugations | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | migration abilities | - |
dc.subject.keywordAuthor | photothermal therapies | - |
dc.subject.keywordPlus | FIBROBLAST-LIKE SYNOVIOCYTES | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | INTERLEUKIN-22 | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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