Inflammation-Targeting Mesenchymal Stem Cells Combined with Photothermal Treatment Attenuate Severe Joint Inflammation
- Authors
- Shin, Min Jun; Park, Jun-Young; Park, Jun Young; Lim, Su Hyun; Lim, Hyoungsu; Choi, Jin Kyeong; Park, Chul-Kyu; Kang, Youn Joo; Khang, Dongwoo
- Issue Date
- Mar-2024
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- arthritis; inflammation-educated mesenchymal stem cells; membrane conjugations; mesenchymal stem cells; migration abilities; photothermal therapies
- Citation
- Advanced Materials, v.36, no.11
- Journal Title
- Advanced Materials
- Volume
- 36
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90780
- DOI
- 10.1002/adma.202304333
- ISSN
- 0935-9648
1521-4095
- Abstract
- Current clinical therapeutic efficacy for the treatment of osteo- and rheumatoid-arthritis is obviously limited. Although mesenchymal stem cells (MSCs) are considered as a source of promising regenerative therapy, un-modified or genetically engineered MSCs injected in vivo restrict their clinical utility because of the low drug efficacy and unpredicted side effect, respectively. Herein, a strategy to enhance the migration efficacy of MSCs to inflamed joints via an inflammation-mediated education process is demonstrated. To reinforce the limited anti-inflammatory activity of MSCs, gold nanostar loaded with triamcinolone is conjugated to MSC. Furthermore, near-infrared laser-assisted photothermal therapy (PTT) induced by gold nanostar significantly elevates the anti-inflammatory efficacy of the developed drugs, even in advanced stage arthritis model. An immunological regulation mechanism study of PTT is first suggested in this study; the expression of the interleukin 22 receptor, implicated in the pathogenesis of arthritis, is downregulated in T lymphocytes by PTT, and Th17 differentiation from naïve CD4 T cell is inhibited. Collectively, inflammation-targeting MSCs conjugated with triamcinolone-loaded gold nanostar (Edu-MSCs-AuS-TA) promote the repolarization of macrophages and decrease neutrophil recruitment in joints. In addition, Edu-MSCs-AuS-TA significantly alleviate arthritis-associated pain, improve general locomotor activity, and more importantly, induce cartilage regeneration even for severe stages of arthritis model. © 2023 Wiley-VCH GmbH.
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