Effectiveness of Bivalent mRNA Booster Vaccine Against COVID-19 in Korea
DC Field | Value | Language |
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dc.contributor.author | Yoon, Jin Gu | - |
dc.contributor.author | Sohn, Jang Wook | - |
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Wie, Seong-Heon | - |
dc.contributor.author | Lee, Jacob | - |
dc.contributor.author | Lee, Jin-Soo | - |
dc.contributor.author | Jeong, Hye Won | - |
dc.contributor.author | Eom, Joong Sik | - |
dc.contributor.author | Seong, Hye | - |
dc.contributor.author | Nham, Eliel | - |
dc.contributor.author | Choi, Yu Jung | - |
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.date.accessioned | 2024-03-29T11:30:15Z | - |
dc.date.available | 2024-03-29T11:30:15Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90827 | - |
dc.description.abstract | Background: Bivalent booster mRNA vaccines containing the omicron-variant strains have been introduced worldwide in the autumn of 2022. Nevertheless, the omicron subvariants evoked another large coronavirus disease 2019 (COVID-19) pandemic wave in late 2022 and early 2023. Methods: A retrospective, test-negative, case-control study was conducted to estimate the vaccine effectiveness (VE) of bivalent COVID-19 vaccines in 8 university hospitals between January and February 2023. The case and control groups were divided based on nasopharyngeal COVID-19 real-time polymerase chain reaction results and matched based on age, sex, hospital, and date (week) of the test performed. The VE of the BA.1-or BA.4/BA.5-based mRNA vaccines were estimated. VE was calculated using the 1-adjusted odds ratio from multivariable logistic regression. Results: In total, 949 patients and 947 controls were enrolled in this study. VE for the BA.4/ BA.5-based bivalent mRNA vaccine was 43% (95% confidence interval [CI], 17, 61%). In subgroup analysis based on age and underlying medical conditions, BA.4/BA.5-based bivalent mRNA vaccine was effective against old adults aged >_ 65-years (VE, 55%; 95% CI, 23, 73%) and individuals with comorbidities (VE, 54%; 95% CI, 23, 73%). In comparison, the BA.1-based bivalent mRNA vaccine did not demonstrate statistically significant effectiveness (VE, 25%; 95% CI, -8, 49%). Conclusion: The BA.4/BA.5-based bivalent mRNA booster vaccine provided significant protection against COVID-19 in the Korean adults, especially in the older adults aged >_ 65 years and in individuals with underlying medical conditions. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Effectiveness of Bivalent mRNA Booster Vaccine Against COVID-19 in Korea | - |
dc.type | Article | - |
dc.identifier.wosid | 001165994500004 | - |
dc.identifier.doi | 10.3346/jkms.2024.39.e15 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.39, no.3, pp 1 - 9 | - |
dc.identifier.kciid | ART003046025 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85183260009 | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | mRNA Vaccine | - |
dc.subject.keywordAuthor | Vaccine Efficacy | - |
dc.subject.keywordAuthor | SARS-CoV-2 Omicron Variant | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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