α-Glucan-type exopolysaccharides with varied linkage patterns: Mitigating post-prandial glucose spike and prolonging the glycemic response
DC Field | Value | Language |
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dc.contributor.author | Lim, Hae-eun | - |
dc.contributor.author | Song, Young -Bo | - |
dc.contributor.author | Choi, Hyun-wook | - |
dc.contributor.author | Lee, Byung-Hoo | - |
dc.date.accessioned | 2024-04-12T00:30:43Z | - |
dc.date.available | 2024-04-12T00:30:43Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.issn | 1879-1344 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90967 | - |
dc.description.abstract | Microbial exopolysaccharides (EPSs) are traditionally known as prebiotics that foster colon health by serving as microbiota nutrients, while remaining undigested in the small intestine. However, recent findings suggest that alpha-glucan structures in EPS, with their varied alpha-linkage types, can be hydrolyzed by mammalian alpha-glucosidases at differing rates. This study explores alpha-glucan-type EPSs, including dextran, alternan, and reuteran, assessing their digestive properties both in vitro and in vivo. Notably, while fungal amyloglucosidase - a common in vitro tool for carbohydrate digestibility analysis - shows limited efficacy in breaking down these structures, mammalian intestinal alpha-glucosidases can partially degrade them into glucose, albeit slowly. In vivo experiments with mice revealed that various EPSs elicited a significantly lower glycemic response (p < 0.05) than glucose, indicating their nature as carbohydrates that are digested slowly. This leads to the conclusion that different alpha-glucan-type EPSs may serve as ingredients that attenuate post -prandial glycemic responses. Furthermore, rather than serving as mere dietary fibers, they hold the potential for blood glucose regulation, offering new avenues for managing obesity, Type 2 diabetes, and other related -chronic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | α-Glucan-type exopolysaccharides with varied linkage patterns: Mitigating post-prandial glucose spike and prolonging the glycemic response | - |
dc.type | Article | - |
dc.identifier.wosid | 001181048600001 | - |
dc.identifier.doi | 10.1016/j.carbpol.2024.121898 | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.331 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85184004816 | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 331 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Exopolysaccharides | - |
dc.subject.keywordAuthor | alpha-Glucans | - |
dc.subject.keywordAuthor | Slowly digestible carbohydrates | - |
dc.subject.keywordAuthor | Glycemic response | - |
dc.subject.keywordAuthor | Small intestinal alpha-glucosidases | - |
dc.subject.keywordPlus | LACTIC-ACID BACTERIA | - |
dc.subject.keywordPlus | SLOWLY DIGESTIBLE STARCH | - |
dc.subject.keywordPlus | LACTOBACILLUS-REUTERI | - |
dc.subject.keywordPlus | PERSPECTIVES | - |
dc.subject.keywordPlus | GLUCOSIDASES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MUTANTS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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