Association between body mass index and three-year outcome of acute myocardial infarctionopen access
- Authors
- Park, Soyoon; Kim, Dae-Won; Lee, Kyusup; Park, Mahn-Won; Chang, Kiyuk; Jeong, Myung Ho; Ahn, Young Keun; Chae, Sung Chull; Ahn, Tae Hoon; Rha, Seung Woon; Kim, Hyo-Soo; Gwon, Hyeon Cheol; Seong, In Whan; Hwang, Kyung Kuk; Kim, Kwon-Bae; Cha, Kwang Soo; Oh, Seok Kyu; Chae, Jei Keon
- Issue Date
- Mar-2024
- Publisher
- NATURE PORTFOLIO
- Citation
- SCIENTIFIC REPORTS, v.14, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 14
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91038
- DOI
- 10.1038/s41598-023-43493-0
- ISSN
- 2045-2322
- Abstract
- Body mass index (BMI), as an important risk factor related to metabolic disease. However, in some studies higher BMI was emphasized as a beneficial factor in the clinical course of patients after acute myocardial infarction (AMI) in a concept known as the "BMI paradox." The purpose of this study was to investigate how clinical outcomes of patients treated for AMI differed according to BMI levels. A total of 10,566 patients in the Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) from May 2010 to June 2015 were divided into three BMI groups (group 1: BMI < 22 kg/m(2), group 2: >= 22 and < 26 kg/m(2), and group 3: >= 26 kg/m(2)). The primary outcome was major adverse cardiac and cerebrovascular event (MACCE) at 3 years of follow-up. At 1 year of follow-up, the incidence of MACCE in group 1 was 10.1% of that in group 3, with a hazard ratio (HR) of 2.27, and 6.5% in group 2, with an HR of 1.415. This tendency continued up to 3 years of follow-up. The study demonstrated that lower incidence of MACCE in the high BMI group of Asians during the 3-year follow-up period compared to the low BMI group. The results implied higher BMI could exert a positive effect on the long-term clinical outcomes of patients with AMI undergoing percutaneous coronary intervention (PCI).
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