A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high-sucrose diet
- Authors
- Lee, Haneul; Kang, Eun Young; Lee, Joowon; Kim, Yejin; Kang, Sumin; Kim, Hayoon; Kim, Hyun Kyung; Gang, Gyoungok; Lee, Sang-gil; Lei, Cao; Go, Gwang-woong
- Issue Date
- May-2024
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Chlorogenic acid; De novo lipogenesis; Hepatic steatosis; Schisandra chinensis; Schisandrin
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.33, no.6, pp 1449 - 1457
- Pages
- 9
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 33
- Number
- 6
- Start Page
- 1449
- End Page
- 1457
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91057
- DOI
- 10.1007/s10068-023-01464-1
- ISSN
- 1226-7708
2092-6456
- Abstract
- Excessive hepatic lipid accumulation is closely linked to inflammation, insulin resistance, and metabolic syndromes. We hypothesized that a combined extract containing Schisandra chinensis (SCE) could alleviate hepatic lipid accumulation. Male Sprague-Dawley rats fed a high-sucrose diet (HSD) were randomly assigned to three groups (n = 6): normal diet (ND), HSD (60% kcal from sucrose), and HSD + SCE (HSD with 2.44% SCE). Liquid chromatography-tandem mass spectrometry revealed that SCE contains chlorogenic acid (5.514 +/- 0.009 mg/g) and schisandrin (0.179 +/- 0.002 mg/g) as bioactive components. SCE did not alter the body weight, fat mass, lean mass, or glucose levels. Strikingly, SCE effectively reduced the plasma triglyceride (TG) and hepatic TG levels compared to the HSD group. Adiposity reduction is due to decreased activity of hepatic de novo lipogenic enzymes. These results indicated that SCE has nutraceutical potential for the prevention and treatment of hepatic steatosis.
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