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Alginate functionalized magnetic-silica composites for pH-responsive drug delivery and magnetic hyperthermia applications
- Authors
- Mohan, Anandhu; Suresh, Ranganathan; Ashwini, Munusamy; Periyasami, Govindasami; Guganathan, Loganathan; Lin, Mei-Ching; Kumarasamy, Keerthika; Kim, Seong-Cheol; Santhamoorthy, Madhappan
- Issue Date
- Apr-2024
- Publisher
- ELSEVIER
- Keywords
- Drug delivery; Silica coating; Magnetic hyperthermia; Magnetic NPs; Biocompatibility
- Citation
- MATERIALS LETTERS, v.361
- Journal Title
- MATERIALS LETTERS
- Volume
- 361
- ISSN
- 0167-577X
1873-4979
- Abstract
- A biopolymer sodium alginate (Alg) functionalized core-shell magnetic silica composite (FeNP@SiOH@Alg) has been proposed for pH-responsive drug delivery and magnetic hyperthermia applications. Various instruments such as XRD, FTIR, SEM, and TGA analysis were accessed to characterize the FeNP@SiOH@Alg. Under the alternating magnetic field (AMF), the magnetic hyperthermia and pH-responsive drug delivery efficiency of the prepared FeNP@SiOH@Alg were examined using doxorubicin (Dox) as a modal drug. Furthermore, the in vitro biocompatibility of the FeNP@SiOH@Alg on MDA-MB-231 cells was examined. All the findings indicated that FeNP@SiOH@Alg is effective for magnetic hyperthermia-based chemotherapy applications in cancer therapy.
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Related Researcher
- Mohan, Anandhu
- Graduate School (Dept. of Nano Science and Technology)