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Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's diseaseopen access
- Authors
- Baek, Daye; Lee, Kun-Gu; Sohn, Hee-Young; Park, Jung Hyun; Lee, Hye-Kyung; Bayarsaikhan, Govigerel; Yoo, Sang-Won; Lee, Bonghee; Kim, Joong-Seok; Koh, Young Ho; Kwon, Munjin
- Issue Date
- Apr-2024
- Publisher
- ELSEVIER
- Citation
- STEM CELL RESEARCH, v.76
- Journal Title
- STEM CELL RESEARCH
- Volume
- 76
- ISSN
- 1873-5061
1876-7753
- Abstract
- Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.
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Related Researcher
- BAYARSAIKHAN, GOVIGEREL
- College of Medicine (Premedical Course)