A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery
- Authors
- Kim, Jihye; Bury, Matthew I.; Kwon, Kyeongha; Yoo, Jae - Young; Halstead, Nadia, V; Shin, Hee-Sup; Li, Shupeng; Won, Sang Min; Seo, Min-Ho; Wu, Yunyun; Park, Do Yun; Kini, Mitali; Kwak, Jean Won; Madhvapathy, Surabhi R.; Ciatti, Joanna L.; Lee, Jae Hee; Kim, Suyeon; Ryu, Hanjun; Yamagishi, Kento; Yoon, Hong- Joon; Kwak, Sung Soo; Kim, Bosung; Huang, Yonggang; Halliday, Lisa C.; Cheng, Earl Y.; Ameer, Guillermo A.; Sharma, Arun K.; Rogers, John A.
- Issue Date
- Apr-2024
- Publisher
- NATL ACAD SCIENCES
- Keywords
- bladder; regeneration; bioelectronics; wireless; sensing
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.121, no.14
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 121
- Number
- 14
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91636
- DOI
- 10.1073/pnas.2400868121
- ISSN
- 0027-8424
1091-6490
- Abstract
- Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient - friendly, they exhibit user - to - user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter - associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high - risk patients. Here, we introduce a fully bladder - implantable platform that allows for continuous, real - time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real - time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long - term postoperative bladder recovery monitoring.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91636)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.