Electrospun fibers modified with polydopamine for enhancing human mesenchymal stem cell culture
DC Field | Value | Language |
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dc.contributor.author | Yang, Da Hyun | - |
dc.contributor.author | Lee, Nae Yoon | - |
dc.date.accessioned | 2024-06-26T11:00:19Z | - |
dc.date.available | 2024-06-26T11:00:19Z | - |
dc.date.issued | 2024-07 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.issn | 1748-605X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91671 | - |
dc.description.abstract | In this study, we coated electrospun polycaprolactone (PCL) fibers with polydopamine (PDA) to modify their hydrophobicity and fabricated a matrix for culturing mesenchymal stem cells (MSCs). Additionally, we incorporated Arg-Gly-Asp (RGD) peptides into PDA to enhance MSCs culture performance on PCL fibers. PDA and RGD were successfully coated in one step by immersing the electrospun fibers in a coating solution, without requiring an additional surface activation process. The characteristics of functionalized PCL fibers were analyzed by scanning electron microscopy with energy-dispersive x-ray analysis, Fourier transform infrared spectroscopy, water contact angle measurement, and fluorescence measurements using a carboxylic-modified fluorescent microsphere. MSCs cultured on the modified PCL fibers demonstrated enhanced cell adhesion, proliferation, and osteogenic- and chondrogenic differentiation. This study provides insight into potential applications for scaffold fabrication in MSCs-based tissue engineering, wound dressing, implantation, and a deeper understanding of MSCs behavior in vitro. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IOP Publishing Ltd | - |
dc.title | Electrospun fibers modified with polydopamine for enhancing human mesenchymal stem cell culture | - |
dc.type | Article | - |
dc.identifier.wosid | 001228970700001 | - |
dc.identifier.doi | 10.1088/1748-605X/ad49f7 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, v.19, no.4 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85194106095 | - |
dc.citation.title | BIOMEDICAL MATERIALS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | polydopamine | - |
dc.subject.keywordAuthor | RGD | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
dc.subject.keywordAuthor | electrospinning | - |
dc.subject.keywordAuthor | fibrous scaffolds | - |
dc.subject.keywordPlus | MEDIATED SURFACE MODIFICATION | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | NANOFIBERS | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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