Ultrasound-Driven On-Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activityopen access
- Authors
- Imani, Iman M.; Kim, Bosung; Xiao, Xiao; Rubab, Najaf; Park, Byung-Joon; Kim, Young-Jun; Zhao, Pin; Kang, Minki; Kim, Sang-Woo
- Issue Date
- Jan-2023
- Publisher
- WILEY
- Keywords
- antibacteria; biodegradable; implantable; triboelectric nanogenerator; ultrasound
- Citation
- ADVANCED SCIENCE, v.10, no.3
- Journal Title
- ADVANCED SCIENCE
- Volume
- 10
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91793
- DOI
- 10.1002/advs.202204801
- ISSN
- 2198-3844
2198-3844
- Abstract
- To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)-driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV-TENG). After a programmed lifetime, the IBV-TENG can be eliminated by provoking the on-demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of approximate to 4 V and current of approximate to 22 mu A generated from IBV-TENG under ultrasound in vitro, confirming inactivating approximate to 100% of Staphylococcus aureus and approximate to 99% of Escherichia coli. Furthermore, ex vivo results show that IBV-TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.
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