Risk of pulmonary embolism and deep vein thrombosis following COVID-19: a nationwide cohort studyopen access
- Authors
- Kim, Hye Jun; Jeong, Seogsong; Song, Jihun; Park, Sun Jae; Park, Young Jun; Oh, Yun Hwan; Jung, Jaehun; Park, Sang Min
- Issue Date
- Jul-2024
- Publisher
- John Wiley and Sons Inc
- Keywords
- embolism; long-term sequelae; postacute COVID-19 syndrome; SARS-CoV-2; thrombosis
- Citation
- MedComm, v.5, no.7
- Journal Title
- MedComm
- Volume
- 5
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/92040
- DOI
- 10.1002/mco2.655
- ISSN
- 2688-2663
2688-2663
- Abstract
- Recent studies elucidate that coronavirus disease 2019 (COVID-19) patients may face a higher risk of cardiovascular complications. This study aimed to evaluate association of COVID-19 with the risk of pulmonary embolism (PE) or deep vein thrombosis (DVT). This nationwide population-based retrospective cohort study included Korean adult citizens between January 2021 and March 2022 from the Korea Disease Control and Prevention Agency COVID-19 National Health Insurance Service cohort. The Fine and Gray's regression with all-cause death as a competing event was adopted to evaluate PE and DVT risks after COVID-19. This study included a total of 1,601,835 COVID-19 patients and 14,011,285 matched individuals without COVID-19. The risk of PE (adjusted hazard ratio [aHR], 6.25; 95% confidence interval [CI], 3.67–10.66; p < 0.001) and DVT (aHR, 3.05; 95% CI, 1.75–5.29; p < 0.001) was higher in COVID-19 group in individuals without complete COVID-19 vaccination. In addition, individuals with complete COVID-19 vaccination still had a higher risk of COVID-19-related PE (aHR, 1.48; 95% CI, 1.15–1.88; p < 0.001). However, COVID-19 was not a significant risk factor for DVT among those with complete COVID-19 vaccination. COVID-19 was identified as an independent factor that elevated PE and DVT risks, especially for individuals without complete COVID-19 vaccination. © 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
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