Assessment of Bone Marrow Involvement in Extranodal NK/T-Cell Lymphoma: Positron Emission Tomography versus Bone Marrow Biopsy, and the Significance of Minimal Involvement by EBV plus Cells (KROG 18-09)
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Kim, Hyun Ju | - |
dc.contributor.author | Lee, Jong Hoon | - |
dc.contributor.author | Lee, Jeongshim | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Oh, Dongryul | - |
dc.contributor.author | Eom, Keun-Yong | - |
dc.date.accessioned | 2024-07-26T12:30:25Z | - |
dc.date.available | 2024-07-26T12:30:25Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.issn | 2005-9256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/92079 | - |
dc.description.abstract | Purpose This study aims to investigate the diagnostic significance of positron emission tomography/computed tomography (PET/ CT) in assessing bone marrow (BM) involvement through a comparison of PET/CT findings with BM biopsy in extranodal natural killer /T -cell lymphoma. Materials and Methods The medical records of 193 patients were retrospectively reviewed. Patients were categorized as having early -stage (PET -ES) or advanced -stage (PET -AS) disease based on PET/CT results. The BM involvement was classified into three groups according to BM biopsy: gross BM involvement, minimal BM involvement (defined as the presence of a limited number of Epstein -Barr virus-positive cells in BM), and no involvement. Calculations of the accuracy of PET/CT in detecting BM involvement and analysis of the clinical outcomes (progression -free survival [PFS] and overall survival [OS]) according to the BM biopsy status were performed. Results PET/CT exhibited a sensitivity of 64.7% and a specificity of 96.0% in detecting gross BM involvement. For detecting any (both gross and minimal) BM involvement, the sensitivity was 30.4%, while the specificity was 99.0%. Only one patient (0.7%) demonstrated gross BM involvement among the PET -ES group. Survival outcomes of the PET -ES group with minimal BM involvement (3 -year PFS, 55.6%; OS, 77.0%) were closer to those of the PET -ES group with no BM involvement (3 -year PFS, 62.2%; OS, 80.6%) than to those of the PET -AS group (3 -year PFS, 20.1%; OS, 29.9%). Conclusion PET/CT exhibits high specificity, but moderate and low sensitivity in detecting gross and minimal BM involvement, respectively. The clinical significance of minimal BM involvement for patients in the PET -ES group may be limited. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.title | Assessment of Bone Marrow Involvement in Extranodal NK/T-Cell Lymphoma: Positron Emission Tomography versus Bone Marrow Biopsy, and the Significance of Minimal Involvement by EBV plus Cells (KROG 18-09) | - |
dc.type | Article | - |
dc.identifier.wosid | 001208949300023 | - |
dc.identifier.doi | 10.4143/crt.2023.1049 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.56, no.2, pp 688 - 696 | - |
dc.identifier.kciid | ART003070504 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85190323299 | - |
dc.citation.endPage | 696 | - |
dc.citation.startPage | 688 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 56 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | NK/T-cell lymphoma | - |
dc.subject.keywordAuthor | Bone marrow | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
dc.subject.keywordAuthor | Minimal involvement | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | NON-HODGKIN-LYMPHOMA | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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