Assessment of Bone Marrow Involvement in Extranodal NK/T-Cell Lymphoma: Positron Emission Tomography versus Bone Marrow Biopsy, and the Significance of Minimal Involvement by EBV plus Cells (KROG 18-09)open access
- Authors
- Lee, Tae Hoon; Kim, Hyun Ju; Lee, Jong Hoon; Lee, Jeongshim; Kim, Jin Hee; Oh, Dongryul; Eom, Keun-Yong
- Issue Date
- Apr-2024
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- NK/T-cell lymphoma; Bone marrow; Positron emission tomography; Minimal involvement
- Citation
- CANCER RESEARCH AND TREATMENT, v.56, no.2, pp 688 - 696
- Pages
- 9
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 56
- Number
- 2
- Start Page
- 688
- End Page
- 696
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/92079
- DOI
- 10.4143/crt.2023.1049
- ISSN
- 1598-2998
2005-9256
- Abstract
- Purpose This study aims to investigate the diagnostic significance of positron emission tomography/computed tomography (PET/ CT) in assessing bone marrow (BM) involvement through a comparison of PET/CT findings with BM biopsy in extranodal natural killer /T -cell lymphoma. Materials and Methods The medical records of 193 patients were retrospectively reviewed. Patients were categorized as having early -stage (PET -ES) or advanced -stage (PET -AS) disease based on PET/CT results. The BM involvement was classified into three groups according to BM biopsy: gross BM involvement, minimal BM involvement (defined as the presence of a limited number of Epstein -Barr virus-positive cells in BM), and no involvement. Calculations of the accuracy of PET/CT in detecting BM involvement and analysis of the clinical outcomes (progression -free survival [PFS] and overall survival [OS]) according to the BM biopsy status were performed. Results PET/CT exhibited a sensitivity of 64.7% and a specificity of 96.0% in detecting gross BM involvement. For detecting any (both gross and minimal) BM involvement, the sensitivity was 30.4%, while the specificity was 99.0%. Only one patient (0.7%) demonstrated gross BM involvement among the PET -ES group. Survival outcomes of the PET -ES group with minimal BM involvement (3 -year PFS, 55.6%; OS, 77.0%) were closer to those of the PET -ES group with no BM involvement (3 -year PFS, 62.2%; OS, 80.6%) than to those of the PET -AS group (3 -year PFS, 20.1%; OS, 29.9%). Conclusion PET/CT exhibits high specificity, but moderate and low sensitivity in detecting gross and minimal BM involvement, respectively. The clinical significance of minimal BM involvement for patients in the PET -ES group may be limited.
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