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pH-responsive drug delivery and antimicrobial efficacy of pectin-polyhexamethylene guanidine-based polyelectrolyte complex biocides
- Authors
- Mohan, Anandhu; Pakiyaraj, Kanakaraj; Santhamoorthy, Madhappan; Ashwini, Munusamy; Suresh, Ranganathan; Pham, Thi Hong Trang; Kim, Seong-Cheol; Lin, Mei- Ching; Phan, Thi Tuong Vy; Kumarasamy, Keerthika
- Issue Date
- Sep-2024
- Publisher
- ELSEVIER
- Keywords
- Polyhexamethylene guanidine; Pectin; Polyelectrolyte complex biocides; Drug delivery; Antimicrobial agent
- Citation
- MATERIALS LETTERS, v.371
- Journal Title
- MATERIALS LETTERS
- Volume
- 371
- ISSN
- 0167-577X
1873-4979
- Abstract
- This study presents a solid-state antimicrobial complex formed by combining pectin (PEC) and polyhexamethylene guanidine (PHMG). The complex exhibits inherent antibacterial activity. Furthermore, curcumin (Cur) was loaded into the complex for drug delivery applications. Cur interacts with the complex through weak electrostatic forces, enabling controlled drug release under mildly acidic conditions. The PEC: PHMG complex with Cur demonstrates enhanced antibacterial efficacy compared to PEC: PHMG alone, making it a promising antimicrobial and drug delivery platform with diverse drug delivery and antimicrobial applications.
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Related Researcher
- Mohan, Anandhu
- Graduate School (Dept. of Nano Science and Technology)