Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Fermented Pueraria Lobata extract ameliorates dextran sulfate sodium-induced colitis by reducing pro-inflammatory cytokines and recovering intestinal barrier function

Authors
최승호우종규장영수강주희장정은이태후박상용김선여윤여성오승현
Issue Date
Sep-2016
Publisher
한국실험동물학회
Keywords
IBD; herbal medicines; Pueraria Lobata; inflammation; intestinal barrier
Citation
Laboratory Animal Research, v.32, no.3, pp.151 - 159
Journal Title
Laboratory Animal Research
Volume
32
Number
3
Start Page
151
End Page
159
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9215
ISSN
1738-6055
Abstract
Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order to eliminate the limitations, herbal medicines have recently been developed for treatment of IBD. Peuraria Lobata (Peuraria L.) is one of the traditional herbal medicines that have anti-inflammatory effects. Bioavailability of Peuraria L., which is rich in isoflavones, is lower than that of their fermented forms. In this study, we generated fermented Peuraria L. extracts (fPue) and investigated the role of fPue in inflammation and intestinal barrier function in vitro and in vivo. As the mice or intestinal epithelial cells were treated with DSS/fPue, mRNA expression of pro-inflammatory cytokines was reduced and the architecture and expression of tight junction proteins were recovered, compared to the DSS-treated group. In summary, fPue treatment resulted in amelioration of DSS-induced inflammation in the colon, and the disrupted intestinal barrier was recovered as the expression and architecture of tight junction proteins were retrieved. These results suggest that use of fPue could be a new therapeutic strategy for treatment of IBD.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Oh, Seung Hyun photo

Oh, Seung Hyun
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE