梔子가 JNK와 NF-kB를 통한 항산화와 항염증의 대사과정에 미치는 영향Effects of Gardeniae Fructus on the metabolic process of antioxidant and anti-inflammation by JNK and NF-kB
- Other Titles
- Effects of Gardeniae Fructus on the metabolic process of antioxidant and anti-inflammation by JNK and NF-kB
- Authors
- 이상철; 심성용; 김연섭
- Issue Date
- 2016
- Publisher
- 대한한방안이비인후피부과학회
- Keywords
- Gardeniae Fuctus; 4-HNE; JNK; NF-kB
- Citation
- 한방안이비인후피부과학회지, v.29, no.2, pp.56 - 64
- Journal Title
- 한방안이비인후피부과학회지
- Volume
- 29
- Number
- 2
- Start Page
- 56
- End Page
- 64
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9442
- DOI
- 10.6114/jkood.2016.29.2.056
- ISSN
- 1738-6640
- Abstract
- Objectives : The purpose of this study is to observe the effects of Gardeniae Fuctus(GF) on the metabolic process of antioxidant and anti-inflammation.
Methods : 4-HNE was injected into PC-12 cell to cause oxidative stress-induced inflammatory response, and then a western blot was conducted to observe the expression of Nuclear Factor-kB (NF-kB) and c-Jun N-terminal kinase (JNK) protein that are important factors involved with inflammation.
Results : 1. The Gardeniae Fuctus water extract 50 ㎍ and 100 ㎍ significantly suppressed the increase in JNK protein expression in PC-12 cell.
2. The Gardeniae Fuctus water extract 50 ㎍, 100 ㎍ and 200 ㎍ significantly suppressed the increase in NF-kB protein expression in PC-12 cell.
Conclusion : These results suggest that the Gardeniae Fuctus water extract has antioxidative and anti-inflammatory activity through suppressing the activity of JNK and NF-kB.
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