갈근탕이 고지방 식이 유발 비만 쥐에서 비만 관련 유전자 발현에 미치는 영향Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice
- Other Titles
- Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice
- Authors
- 예성애; 김호준; 고성규; 송윤경
- Issue Date
- 2016
- Publisher
- 한방재활의학과학회
- Keywords
- Galgeun-tang (gegentang); obesity; orlistat Galgeun; Mahwang; Obesity- related genes
- Citation
- 한방재활의학과학회지, v.26, no.2, pp.1 - 12
- Journal Title
- 한방재활의학과학회지
- Volume
- 26
- Number
- 2
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9489
- ISSN
- 1229-1854
- Abstract
- ObjectivesThe purpose of this study was to evaluate anti-obesity effect of Galgeun- tang (gegentang) and elucidate the effect of it on gene expression related to obesity.MethodsThe experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to inves-tigate the effect of GGT on gene expression in liver tissue.ResultsGGT group and ORL group were reduced in body weight compared with HFD. HFD increased PPARγ, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced PPARγ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. ConclusionsThese results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future. (J Korean Med Rehab 2016;26(2):1-12)
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