갈근탕이 고지방 식이 유발 비만 쥐에서 비만 관련 유전자 발현에 미치는 영향

Abstract

ObjectivesThe purpose of this study was to evaluate anti-obesity effect of Galgeun- tang (gegentang) and elucidate the effect of it on gene expression related to obesity.MethodsThe experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to inves-tigate the effect of GGT on gene expression in liver tissue.ResultsGGT group and ORL group were reduced in body weight compared with HFD. HFD increased PPARγ, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced PPARγ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. ConclusionsThese results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future. (J Korean Med Rehab 2016;26(2):1-12)