Fimasartan for independent reduction of blood pressure variability in mild-to-moderate hypertension
- Authors
- Shin, Mi-Seung; Kang, Dae Ryong; Kim, Changsoo; Cho, Eun Joo; Sung, Ki-Chul; Kang, Seok-Min; Kim, Dong-Soo; Joo, Seung Jae; Lee, Seung Hwan; Hwang, Kyung-Kuk; Park, Jeong Bae
- Issue Date
- 2016
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- angiotensin receptor blockers; hypertension; blood pressure variability
- Citation
- DRUG DESIGN DEVELOPMENT AND THERAPY, v.10, pp.1573 - 1580
- Journal Title
- DRUG DESIGN DEVELOPMENT AND THERAPY
- Volume
- 10
- Start Page
- 1573
- End Page
- 1580
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9675
- DOI
- 10.2147/DDDT.S107433
- ISSN
- 1177-8881
- Abstract
- Background: The angiotensin receptor antagonist fimasartan lowered blood pressure (BP) in a previous large population study. The purpose of this study was to evaluate whether fimasartan treatment for 3 months affects clinical and home BP variability in addition to reducing BP. Methods: The study enrolled 1,396 patients (mean age 56.2 +/- 10.0 years; males 53.6%) with mild-to-moderate hypertension who had a complete set of home BP measurements (morning and evening) and metabolic risk evaluation. During the 3 months of study, fimasartan alone was used to control BP at a daily dose of 30-120 mg. Clinical and home BP measurements were performed before and after the 3-month treatment. BP variability included beat-to-beat variability (clinical) and day-to-day variability (home). Results: Fimasartan reduced BP after 3 months of treatment. The average reduction of clinical systolic BP (c-SBP) was 15.08 +/- 18.36 mmHg (P<0.0001), and the average reduction of morning home SBP (m-SBP) was 11.49 +/- 19.33 mmHg (P<0.0001). Beat-to-beat variability as standard deviation (SD) of c-SBP was reduced from 4.56 +/- 3.22 to 4.24 +/- 3.11 mmHg (P=0.0026). Day-today variability as SD of m-SBP was reduced from 7.92 +/- 6.74 to 6.95 +/- 4.97 mmHg (P<0.0001). Multiple regression analysis revealed an independent association between the change in the SD of c-SBP and the change in c-SBP (P=0.0268) and, similarly, between the change in the SD of m-SBP and the change in m-SBP (P=0.0258), after adjusting for age, sex, body mass index, and change in mean BP. Conclusion: This study indicated that 3 months of fimasartan treatment reduced day-to-day BP variability independent of BP reduction in patients with hypertension.
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