Triamcinolone-carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Lee, Yeon Kyung | - |
dc.contributor.author | Choi, Jin Kyeong | - |
dc.contributor.author | Kang, Youn Joo | - |
dc.contributor.author | Kim, Hye Won | - |
dc.contributor.author | Kim, Sang-Woo | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.date.available | 2020-02-28T06:43:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9699 | - |
dc.description.abstract | Repetitive intra-articular corticosteroid injections are inevitable for treating synovial inflammation in advanced arthritis. However, short- and long-term use of corticosteroids usually triggers serious side effects (i.e., adrenal insufficiency, hyperglycemia, Cushing syndrome, osteoporosis, Charcot arthropathy, etc.). This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethyleneglycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1 beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Specifically, conjugation of triamcinolone and multi-walled carbon nanotubes inactivated nuclear factor-kappa B via inhibition of the phosphorylation of mitogen-activated protein kinases and the serine/threonine kinase Akt. In summary, low-dose triamcinolone conjugation with carbon nanotubes significantly inhibited the inflammatory response of fibroblast-like synoviocytes by achieving highly efficient intracellular trafficking and suggested a potential drug candidate for resolving side effects associated with conventional arthritis treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | METHYLPREDNISOLONE ACETATE | - |
dc.subject | ACETONIDE | - |
dc.subject | MATRIX | - |
dc.subject | CELLS | - |
dc.subject | KNEE | - |
dc.subject | INJECTIONS | - |
dc.subject | STRATEGIES | - |
dc.subject | CYTOKINES | - |
dc.title | Triamcinolone-carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000371062000010 | - |
dc.identifier.doi | 10.1039/c5tb01693b | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.4, no.9, pp.1660 - 1671 | - |
dc.identifier.scopusid | 2-s2.0-84959421101 | - |
dc.citation.endPage | 1671 | - |
dc.citation.startPage | 1660 | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 4 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, Yeon Kyung | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kyu | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | METHYLPREDNISOLONE ACETATE | - |
dc.subject.keywordPlus | ACETONIDE | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | KNEE | - |
dc.subject.keywordPlus | INJECTIONS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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