Triamcinolone-carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts
- Authors
- Lee, Yeon Kyung; Choi, Jin Kyeong; Kang, Youn Joo; Kim, Hye Won; Kim, Sang-Woo; Park, Chul-Kyu; Khang, Dongwoo; Kim, Sang-Hyun
- Issue Date
- 2016
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B, v.4, no.9, pp.1660 - 1671
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY B
- Volume
- 4
- Number
- 9
- Start Page
- 1660
- End Page
- 1671
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9699
- DOI
- 10.1039/c5tb01693b
- ISSN
- 2050-750X
- Abstract
- Repetitive intra-articular corticosteroid injections are inevitable for treating synovial inflammation in advanced arthritis. However, short- and long-term use of corticosteroids usually triggers serious side effects (i.e., adrenal insufficiency, hyperglycemia, Cushing syndrome, osteoporosis, Charcot arthropathy, etc.). This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethyleneglycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1 beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Specifically, conjugation of triamcinolone and multi-walled carbon nanotubes inactivated nuclear factor-kappa B via inhibition of the phosphorylation of mitogen-activated protein kinases and the serine/threonine kinase Akt. In summary, low-dose triamcinolone conjugation with carbon nanotubes significantly inhibited the inflammatory response of fibroblast-like synoviocytes by achieving highly efficient intracellular trafficking and suggested a potential drug candidate for resolving side effects associated with conventional arthritis treatment.
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