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Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice
- Authors
- Kwon, Yoon Kyung; Choi, Soo Jung; Kim, Cho Rong; Kim, Jae Kyeom; Kim, Hye Kyung; Choi, Jong Hun; Song, Sang-Wook; Kim, Chang-Ju; Park, Gwi Gun; Park, Cheung-Seog; Shin, Dong-Hoon
- Issue Date
- Dec-2015
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Chaenomeles sinensis; learning; memory; cognitive impairment; stearic acid methyl ester; choline acetyltransferase
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.63, no.12, pp.1076 - 1080
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 63
- Number
- 12
- Start Page
- 1076
- End Page
- 1080
- ISSN
- 0009-2363
- Abstract
- The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenotneles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [C-14]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.
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