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Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug
- Authors
- Nguyen-Thach Tung; Vu-Thu Huyen; Chi, Sang-Cheol
- Issue Date
- Nov-2015
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Dexamethasone acetate; Nanostructured lipid carrier; Hydrogel; Skin deposition; Permeation rate
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.38, no.11, pp.1999 - 2007
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 38
- Number
- 11
- Start Page
- 1999
- End Page
- 2007
- ISSN
- 0253-6269
- Abstract
- The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
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Related Researcher
- Chi, Sang Cheol
- Pharmacy (Dept.of Pharmacy)