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Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review
- Authors
- Lim, Dae Hyun; Yoon, Jai Hoon; Jun, Dae Won; Lee, Oh Young; Yoon, Byung Chul; Lee, Hang Rak; Kim, Kyung Soo; Choi, Ho Soon
- Issue Date
- Mar-2020
- Publisher
- 대한간암학회
- Keywords
- Sorafenib; Coronary artery vasospasm; Variant angina; Tyrosine kinase inhibitor; Vascular endothelial growth factor inhibitor
- Citation
- 대한간암학회지, v.20, no.1, pp 67 - 71
- Pages
- 5
- Indexed
- KCI
- Journal Title
- 대한간암학회지
- Volume
- 20
- Number
- 1
- Start Page
- 67
- End Page
- 71
- ISSN
- 2288-8128
2383-5001
- Abstract
- Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment.
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Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
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Related Researcher
- Jun, Dae Won
- 서울 의과대학 (DEPARTMENT OF INTERNAL MEDICINE)