Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasomeopen access

Authors
Kim, Hyun YoungChoi, Young JaeKim, Sang KyumKim, HyunsungJun, Dae WonYoon, KyungrokKim, NayounHwang, JungwookKim, Young-MiLim, Sung ChulKang, Keon Wook
Issue Date
Jun-2021
Publisher
NATURE RESEARCH
Citation
COMMUNICATIONS BIOLOGY, v.4, no.1, pp.1 - 15
Indexed
SCIE
SCOPUS
Journal Title
COMMUNICATIONS BIOLOGY
Volume
4
Number
1
Start Page
1
End Page
15
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1143
DOI
10.1038/s42003-021-02345-1
ISSN
2399-3642
Abstract
Demand for a cure of liver fibrosis is rising with its increasing morbidity and mortality. Therefore, it is an urgent issue to investigate its therapeutic candidates. Liver fibrosis progresses following ‘multi-hit’ processes involving hepatic stellate cells, macrophages, and hepatocytes. The NOD-like receptor protein 3 (NLRP3) inflammasome is emerging as a therapeutic target in liver fibrosis. Previous studies showed that the anti-rheumatic agent auranofin inhibits the NLRP3 inflammasome; thus, this study evaluates the antifibrotic effect of auranofin in vivo and explores the underlying molecular mechanism. The antifibrotic effect of auranofin is assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. Moreover, hepatic stellate cell (HSC), bone marrow-derived macrophage (BMDM), kupffer cell, and hepatocyte are used to examine the underlying mechanism of auranofin. Auranofin potently inhibits activation of the NLRP3 inflammasome in BMDM and kupffer cell. It also reduces the migration of HSC. The underlying molecular mechanism was inhibition of cystine-glutamate antiporter, system Xc. Auranofin inhibits system Xc activity and instantly induced oxidative burst, which mediated inhibition of the NLRP3 inflammasome in macrophages and HSCs. Therefore, to the best of our knowledge, we propose the use of auranofin as an anti-liver fibrotic agent.
Files in This Item
Appears in
Collections
서울 의과대학 > 서울 내과학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jun, Dae Won photo

Jun, Dae Won
COLLEGE OF MEDICINE (DEPARTMENT OF INTERNAL MEDICINE)
Read more

Altmetrics

Total Views & Downloads

BROWSE