Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathyopen access
- Authors
- Kim, Hyung Sook; Lee, Jae Seob; Lee, Hong Kyung; Park, Eun Jae; Jeon, Hye Won; Kang, Yu Jeong; Lee, Tae Yong; Kim, Kyung Suk; Bae, Sang-Cheol; Park, Ji Hyun; Han, Sang-Bae
- Issue Date
- Oct-2019
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- Mesenchymal stem cells; Inflammation; Podocytes; Fibrosis
- Citation
- IMMUNE NETWORK, v.19, no.5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 19
- Number
- 5
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12477
- DOI
- 10.4110/in.2019.19.e36
- ISSN
- 1598-2629
2092-6685
- Abstract
- Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the survival, recovered body weight loss, and decreased proteinuria and serum creatinine levels in ADR-treated mice. MSCs also prevented podocyte damage and renal fibrosis by decreasing the expression of fibronectin, collagen 1 alpha 1, and alpha-smooth muscle actin. From a mechanistic perspective, MSCs inhibited renal inflammation by lowering the expression of CCL4, CCL7, CCL19, IFN-alpha/beta, TGF-beta, TNF-alpha, and chitinase 3-like 1. In summary, our data demonstrate that MSCs improve renal functions by inhibiting renal inflammation in ADR-induced nephropathy.
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