Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studiesopen access
- Authors
- Kim, Juno; Chung, Hye Soo; Choi, Min-Kyu; Roh, Yong Kyun; Yoo, Hyung Joon; Park, Jung Hwan; Kim, Dong Sun; Yu, Jae Myung; Moon, Shinje
- Issue Date
- Aug-2019
- Publisher
- KOREAN DIABETES ASSOC
- Keywords
- Antioxidants; Diabetes mellitus; Selenium; Trace elements
- Citation
- DIABETES & METABOLISM JOURNAL, v.43, no.4, pp 447 - 460
- Pages
- 14
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- DIABETES & METABOLISM JOURNAL
- Volume
- 43
- Number
- 4
- Start Page
- 447
- End Page
- 460
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13258
- DOI
- 10.4093/dmj.2018.0123
- ISSN
- 2233-6079
2233-6087
- Abstract
- Background: Epidemiological studies have suggested an association between selenium (Se) and diabetes mellitus (DM). However, different studies have reported conflicting results. Therefore, we performed a comprehensive meta-analysis to clarify the impact of Se on DM.
Methods: We searched the PubMed database for studies on the association between Se and DM from inception to June 2018.
Results: Twenty articles evaluating 47,930 participants were included in the analysis. The meta-analysis found that high levels of Se were significantly associated with the presence of DM (pooled odds ratios [ORs], 1.88; 95% confidence interval [CI], 1.44 to 2.45). However, significant heterogeneity was found (I-2=82%). Subgroup analyses were performed based on the Se measurement methods used in each study. A significant association was found between high Se levels and the presence of DM in the studies that used blood (OR, 2.17; 95% CI, 1.60 to 2.93; I-2 =77%), diet (OR, 1.61; 95% CI, 1.10 to 2.36; I-2 =0%), and urine (OR, 1.49; 95% CI, 1.02 to 2.17; I-2 = 0%) as samples to estimate Se levels, but not in studies on nails (OR, 1.24; 95% CI, 0.52 to 2.98; I-2 = 91%). Because of significant heterogeneity in the studies with blood, we conducted a sensitivity analysis and tested the publication bias. The results were consistent after adjustment based on the sensitivity analysis as well as the trim and fill analysis for publication bias.
Conclusion: This meta-analysis demonstrates that high levels of Se are associated with the presence of DM. Further prospective and randomized controlled trials are warranted to elucidate the link better.
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