Causal relationship between years of education and the occurrence of rheumatoid arthritis
- Authors
- Bae, Sang-Cheol; Lee, Young Ho
- Issue Date
- Jul-2019
- Publisher
- BMJ PUBLISHING GROUP
- Keywords
- mendelian randomization; educational attainment; rheumatoid arthritis
- Citation
- POSTGRADUATE MEDICAL JOURNAL, v.95, no.1125, pp.378 - 381
- Indexed
- SCIE
SCOPUS
- Journal Title
- POSTGRADUATE MEDICAL JOURNAL
- Volume
- 95
- Number
- 1125
- Start Page
- 378
- End Page
- 381
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13353
- DOI
- 10.1136/postgradmedj-2018-136374
- ISSN
- 0032-5473
- Abstract
- Objective To search out whether or not years of education is causally related to rheumatoid arthritis (RA). Method We conducted a two-sample Mendelian randomisation (MR) analysis employing inverse-variance weighted (IVW), weighted median and MR-Egger regression analysis. We chose statistic data of years of education from the UK Biobank genome-wide association studies (GWASs) (n=293 723) as the exposure and a meta-analysis of GWASs of RA with autoantibody (n=5539) and European controls (n=20 169) as the outcome. Results We selected a total of 49 single nucleotide polymorphisms as instrumental variables (IVs). The IVW method instructed an inverse causative relationship between years of education and RA (beta=- 0.039, SE=0.283, p=0.008). MR-Egger regression test showed that directional pleiotropy seems not to bias the MR results (intercept=0.028; p=0.358). MR-Egger analysis demonstrated no causative relationship between RA and years of education (beta=- 2.320, SE=1.709, p=0.181). However, the weighted median approach indicated a causative association between RA and years of education (beta=-0.950, SE=0.355, p=0.008). Conclusions The MR analysis supported a potential inverse causative relationship between years of education and development of RA.
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